Los Jovenes is a culturally responsive, bilingual, prevention education project that helps to combat the ravaging epidemic of opioid misuse, funded by the AmerisourceBergen Foundation. The project focuses on building resiliency skills and increasing knowledge through the exploration and development of protective factors to reduce risk factors associated with substance misuse. The project serves Latino youth, between the ages of 12-20, in three border school districts: Tucson Unified School District, Sunnyside Unified School District, and the Chicanos Por la Causa District. Goals of the project include the increase, strengthening, and enhancing of community collaboration among schools and community partners, while increasing youth and parental awareness through education on the devastating risks and public health problems caused by the misuse and abuse of opioids. Los Jovenes partners with Envision High School in the Chicanos Por la Causa District, Apollo Middle School and Challenger Middle School in the Sunnyside District, Pueblo High School in Tucson Unified School District and Paulo Freire Freedom School and City High School. Los Jovenes is currently in its second year of implementation and has reached over 200 youth in Tucson.