Luke Salcido was born in Tucson Arizona. Raised on the South and West side of Tucson, Luke has witnessed the evolution of the Tucson landscape and people throughout his life. Much of his early life took shape within the first few miles of south 12th Avenue. His maternal great grandfather, Jesus Mercado owned and operated a Mercado and panaderia on south 12th Avenue. His paternal grandparents, Joe and Julia Salcido were pastors of the first apostolic church located on 12th Avenue. Luke graduated from Tucson High Magnet School in 2004. During his time at Tucson High, Salcido was a part of the Mexican American Raza Studies program as a student and intern.

Luke began his non-profit work at Chicanos Por La Causa working in a Latino/a voter registration program and a reading tutor for elementary schools in the Tucson area. In 2007 he began his work at Pima Prevention Partnership working with youth involved in the Juvenile Justice system at Sin Puertas clinical outpatient program in an intensive day support program providing substance abuse and life skills counseling to youth from the Tucson area. Luke served as a physical education/ health instructor at Pima Partnership Academy middle school during the 2011/2012 school year. He spent a year as Director of Adult Day programming with AzMasquerade where he worked with adults and children with various cognitive abilities.

In 2013, Luke returned to Pima Prevention Partnership to work with the Teen Cuisine program a workforce development program working with youth ages 14-24 to develop skills to enter the workforce. Luke has joined Amistades as a Prevention Specialist with the Your Story program a collaborative effort with the Southern Arizona AIDS foundation to prevent and reduce substance use, HIV and Hepatitis transmission by reaching Latino, Native American and LGBTQ youth ages 13-24.